Search Result

Results for "

ROS generation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROS Kinase (4) Akt (2) AMPK (1) Antibiotic (4) Apoptosis (32) Autophagy (10) Bacterial (7) Bcl-2 Family (2) c-Myc (1) Calcium Channel (4) Caspase (2) Cholinesterase (ChE) (1) Complement System (1) COX (1) Endogenous Metabolite (8) ERK (1) Estrogen Receptor/ERR (2) HBV (1) HDAC (3) Isotope-Labeled Compounds (4) JAK (2) JNK (1) Keap1-Nrf2 (3) Lipoxygenase (1) MDM-2/p53 (2) Microtubule/Tubulin (3) MMP (2) Monoamine Oxidase (1) NADPH Oxidase (2) NF-κB (4) NKCC (1) Notch (1) p38 MAPK (1) Parasite (4) PDHK (1) PI3K (2) RAR/RXR (1) Reactive Oxygen Species (51) SGLT (1) Sirtuin (1) Toll-like Receptor (TLR) (1) Topoisomerase (6) Xanthine Oxidase (1)
By Research Areas:	Cancer (47) Cardiovascular Disease (6) Infection (2) Inflammation/Immunology (15) Metabolic Disease (11) Neurological Disease (6)

By Targets:

ROS Kinase (4)

Akt (2)

AMPK (1)

Antibiotic (4)

Apoptosis (32)

Autophagy (10)

Bacterial (7)

Bcl-2 Family (2)

c-Myc (1)

Calcium Channel (4)

Caspase (2)

Cholinesterase (ChE) (1)

Complement System (1)

COX (1)

Endogenous Metabolite (8)

ERK (1)

Estrogen Receptor/ERR (2)

HBV (1)

HDAC (3)

Isotope-Labeled Compounds (4)

JAK (2)

JNK (1)

Keap1-Nrf2 (3)

Lipoxygenase (1)

MDM-2/p53 (2)

Microtubule/Tubulin (3)

MMP (2)

Monoamine Oxidase (1)

NADPH Oxidase (2)

NF-κB (4)

NKCC (1)

Notch (1)

p38 MAPK (1)

Parasite (4)

PDHK (1)

PI3K (2)

RAR/RXR (1)

Reactive Oxygen Species (51)

SGLT (1)

Sirtuin (1)

Toll-like Receptor (TLR) (1)

Topoisomerase (6)

Xanthine Oxidase (1)

By Research Areas:

Cancer (47)

Cardiovascular Disease (6)

Infection (2)

Inflammation/Immunology (15)

Metabolic Disease (11)

Neurological Disease (6)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: ROS Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2410

N-trans-Feruloyltyramine N-feruloyltyramine; Moupinamide	Reactive Oxygen Species Apoptosis	Inflammation/Immunology
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H₂O₂-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research .

HY-18258

Berberine chloride Maximum Cited Publications 37 Publications Verification Natural Yellow 18 chloride	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite	Cancer
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-131003

Taletrectinib 1 Publications Verification DS-6051b; AB-106; IBI-344	ROS Kinase	Cancer
Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective *ROS1/NTRK* inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants .

HY-17577

Berberine chloride hydrate 35+ Cited Publications Natural Yellow 18 chloride hydrate	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite	Cancer
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N8724

Lamalbid

ROS Kinase Others

Lamalbid is a natural product that can be found in Lantana montevidensis. Lamalbid inhibits ROS generation .

Lamalbid	ROS Kinase	Others
Lamalbid is a natural product that can be found in Lantana montevidensis. Lamalbid inhibits ROS generation .

HY-131003A

Taletrectinib free base DS-6051b free base; AB-106 free base; IBI-344 free base	ROS Kinase	Cancer
Taletrectinib (DS-6051b) free base is a potent, orally active, and next-generation selective *ROS1/NTRK* inhibitor. Taletrectinib free base potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib free base also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants .

HY-N3096

Penduletin	Apoptosis Reactive Oxygen Species	Cancer
Penduletin is a flavone, that can be isolated from Brickelia pendula and Vitex negundo. Penduletin shows anticancer activity. Penduletin induces apoptosis in the cancer cells through *ROS* generation .

HY-142956

ROS-ERS inducer 1	Reactive Oxygen Species	Cancer
ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin .

HY-109654

Ensulizole	Reactive Oxygen Species	Metabolic Disease
Ensulizole is a sulfonated UV absorber and can intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation .

HY-18258S

Berberine-d6 chloride Natural Yellow 18-d₆(chloride)	Isotope-Labeled Compounds Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite	Cancer
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].

HY-N2585

Isodeoxyelephantopin	Reactive Oxygen Species NF-κB Autophagy	Cancer
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .

HY-N12233

Condurango glycoside A	Apoptosis MDM-2/p53 Reactive Oxygen Species	Cancer
Condurango glycoside A is an activator of p53. Condurango glycoside A initiates *ROS* generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells .

HY-N12653

Exserohilone (-)-Exserohilone	Reactive Oxygen Species	Metabolic Disease
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced *ROS* generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

HY-116506

Bigelovin	RAR/RXR Reactive Oxygen Species Apoptosis Autophagy	Cancer
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-146048

Antitumor agent-57	Apoptosis Reactive Oxygen Species	Cancer
Antitumor agent-57 (Compound 3o) is an NQO1-directed antitumor agent. Antitumor agent-57 inhibits tumor cell growth, triggers *ROS* generation and induces cell apoptosis .

HY-113978

6-Formylpterin	Xanthine Oxidase Apoptosis Reactive Oxygen Species	Metabolic Disease
6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells .

HY-N6020A

(+)-Butin	Others	Others
(+)-Butin is the R enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities .

HY-150571

Anticancer agent 76	Topoisomerase c-Myc Apoptosis ROS Kinase	Cancer
Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes *ROS* generation and induces cell apoptosis .

HY-N2693

6,8-Diprenylorobol	Apoptosis Reactive Oxygen Species Caspase Akt ERK JNK p38 MAPK Bcl-2 Family	Cancer
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS .

HY-N6884

Bixin 1 Publications Verification	Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology Cancer
Bixin (BX), isolated from the seeds of Bixa orellana, is a carotenoid, possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation .

HY-N0716B

Berberine sulfate 30+ Cited Publications Natural Yellow 18 sulfate	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite	Inflammation/Immunology
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

HY-Y0445A

Sodium dichloroacetate 10+ Cited Publications	PDHK Reactive Oxygen Species NKCC Apoptosis	Cancer
Sodium dichloroacetate is a metabolic regulator in cancer cells' mitochondria with anticancer activity. Sodium dichloroacetate inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. Sodium dichloroacetate increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. Sodium dichloroacetate also works as NKCC inhibitor .

HY-100581

CORM-3
CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation .

HY-N1306

Sideroxylin	Bacterial Reactive Oxygen Species Apoptosis	Infection Cancer
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against *Staphylococcus aureus. Sideroxylin inhibits ovarian cancer cell proliferation and induces apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation* of reactive oxygen species (ROS) .

HY-N10431

Stigmane B	Keap1-Nrf2	Neurological Disease
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-150228

MitoCur-1	Others	Cancer
MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy .

HY-N4278

Huangjiangsu A	Reactive Oxygen Species	Inflammation/Immunology
Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin, isolated from D. villosa. Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation and could be promising as potential therapeutic agents for liver diseases .

HY-155785

MTP	Apoptosis Autophagy Reactive Oxygen Species JAK	Cancer
MTP is a PKM2 inhibitor. MTP induces cancer cell apoptosis by modulating caspase-3 activation. MTP induces autophagy and increases *ROS* generation. MTP also inhibits JAK2 signaling. MTP can be used for research of oral squamous cell carcinoma .

HY-109654R

Ensulizole (Standard)	Reactive Oxygen Species	Metabolic Disease
Ensulizole (Standard) is the analytical standard of Ensulizole. This product is intended for research and analytical applications. Ensulizole is a sulfonated UV absorber and can intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation .

HY-N0232

Psoralidin 4 Publications Verification	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial	Cancer
Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces *ROS* generation .

HY-N3239

Mulberrofuran G	NADPH Oxidase HBV
Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress . Mulberrofuran G shows moderate inhibiting activity of hepatitis B virus (HBV) DNA replication with IC₅₀ of 3.99 μM .

HY-10498

Lexibulin 1 Publications Verification CYT-997	Microtubule/Tubulin Reactive Oxygen Species Apoptosis	Cancer
Lexibulin (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo . Lexibulin induces cell apoptosis and induces mitochondrial *ROS* generation in GC cells .

HY-12805

ML171 10+ Cited Publications 2-Acetylphenothiazine; 2-APT	NADPH Oxidase	Cardiovascular Disease
ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC₅₀ of 0.25 μM in HEK293-Nox1 confirmatory assay.

HY-10498A

Lexibulin dihydrochloride CYT-997 dihydrochloride	Microtubule/Tubulin Reactive Oxygen Species Apoptosis	Cancer
Lexibulin dihydrochloride (CYT-997 dihydrochloride) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo . Lexibulin dihydrochloride induces cell apoptosis and induces mitochondrial *ROS* generation in GC cells .

HY-B0464A

Hydralazine	Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Hydralazine is a orally active antihypertensive agent, reduces peripheral resistance directly by relaxing the smooth muscle cell layer in arterial vessel. Hydralazine has antioxidant activity, as well as inhibits reactive oxygen species (ROS) release and O₂ ^·- generation with an IC₅₀ value of 9.53 mM and 1.19 mM, respectively .

HY-149369

HDAC-IN-59	HDAC Apoptosis	Cancer
HDAC-IN-59 (compound 13a) is a potent histone deacetylase (HDAC) inhibitor. HDAC-IN-59 can promote the intracellular generation of ROS, cause DNA damage, block the cell cycle at G2/M phase, and activate the mitochondria-related apoptotic pathway to induce cell apoptosis .

HY-149370

HDAC-IN-60	HDAC Apoptosis	Cancer
HDAC-IN-60 (compound 21a) is a potent histone deacetylase (HDAC) inhibitor. HDAC-IN-60 can promote the intracellular generation of ROS, cause DNA damage, block the cell cycle at G2/M phase, and activate the mitochondria-related apoptotic pathway to induce cell apoptosis .

HY-N2008

Luteolin 5-O-glucoside
Luteolin 5-O-glucoside, a major flavonoidfrom Cirsium maackii, possesses anti-inflammatory activity. Luteolin 5-O-glucoside inhibits LPS-induced NO production and t-BHP-induced *ROS* generation. Luteolin 5-O-glucoside suppresses the expression of iNOS and COX-2 in macrophages .

HY-D1468

Phototherapeutic agent-1	Reactive Oxygen Species	Cancer
Phototherapeutic agent-1 is a multi-modal light diagnosis agent with aggregation-induced emission properties. have certain Phototherapeutic agent-1 has certain reactive oxygen species (ROS) generation capacity in illumination condition. Phototherapeutic agent-1 can effectively kill cancer cells and tumor tissue .

HY-146063

Anticancer agent 54	Apoptosis	Cancer
Anticancer agent 54 is a potent anticancer agent. Anticancer agent 54 shows antiproliferative activity. Anticancer agent 54 induces apoptosis and cell cycle arrest at G0/G1 phases. Anticancer agent 54 shows anticancer activity depends on DNA intercalation and ROS generation .

HY-D1078

5(6)-Carboxy-2',7'-dichlorofluorescein diacetate	Reactive Oxygen Species	Others
5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell permeant fluorescent indicator. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate can be used to assess reactive oxygen species (ROS) generation within human neuronal-glial (HNG) cells in primary co-culture

HY-N10638

N-Acetyldopamine dimer-2	Reactive Oxygen Species NF-κB	Inflammation/Immunology
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity .

HY-N0457

Chicoric acid 1 Publications Verification Cichoric acid; Dicaffeoyltartaric acid	Reactive Oxygen Species Apoptosis	Metabolic Disease Inflammation/Immunology
Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects .

HY-N0716

Berberine Natural Yellow 18	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Endogenous Metabolite Antibiotic Parasite	Inflammation/Immunology Cancer
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-111226

GSK5182 2 Publications Verification	Estrogen Receptor/ERR Reactive Oxygen Species	Cardiovascular Disease Cancer
GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC₅₀ of 79 nM. GSK5182 does not interact with other nuclear receptors, including ERRα or ERα. GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma (HCC) .

HY-N3071

Picrasidine I	Apoptosis Reactive Oxygen Species	Inflammation/Immunology
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and *ROS* generation, and suppresses the expression of c-Fos and NFATc1 .

HY-N8413

Chlojaponilactone B	Toll-like Receptor (TLR) Reactive Oxygen Species NF-κB	Inflammation/Immunology
Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α .

HY-163090

HR488B	HDAC Reactive Oxygen Species Apoptosis	Cancer
HR488B is an efficient HDAC1 inhibitor. HR488B specifically suppressed the growth of CRC cells by inducing cell cycle G0/G1 arrest and apoptosis. HR488B causes mitochondrial dysfunction, reactive oxygen species (ROS) generation, and DNA damage accumulation .

HY-13413

Tofogliflozin (hydrate) 4 Publications Verification CSG-452 hydrate	SGLT Reactive Oxygen Species	Metabolic Disease
Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with an IC₅₀ of 2.9 nM and K_i values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2 . Tofogliflozin partially inhibits high glucose-induced reactive oxyen species (ROS) generation in tubular cells .

HY-151985

TACC3 inhibitor 1	Apoptosis	Cancer
TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2410

N-trans-Feruloyltyramine N-feruloyltyramine; Moupinamide	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Piperaceae Plants Inflammation/Immunology Disease Research Fields Piper nigrum Linn.	Reactive Oxygen Species Apoptosis
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H₂O₂-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research .

HY-18258

Berberine chloride Maximum Cited Publications 37 Publications Verification Natural Yellow 18 chloride	Alkaloids Structural Classification Phellodendron amurense Rupr. Classification of Application Fields Source classification Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-17577

Berberine chloride hydrate 35+ Cited Publications Natural Yellow 18 chloride hydrate	Alkaloids Structural Classification Classification of Application Fields Source classification Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Antibiotic Endogenous Metabolite Parasite
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N8724

Lamalbid	Structural Classification Verbenaceae Source classification Plants Saccharides Monosaccharides Lantana montevidensis Briq.	ROS Kinase
Lamalbid is a natural product that can be found in Lantana montevidensis. Lamalbid inhibits ROS generation .

HY-N3096

Penduletin	Structural Classification Flavonoids Flavones Verbenaceae Source classification Enkianthus quinqueflorus Lour. Plants Ericaceae	Apoptosis Reactive Oxygen Species
Penduletin is a flavone, that can be isolated from Brickelia pendula and Vitex negundo. Penduletin shows anticancer activity. Penduletin induces apoptosis in the cancer cells through *ROS* generation .

HY-N2585

Isodeoxyelephantopin	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Amorpha fruticosaL. Plants Compositae Disease Research Fields Cancer	Reactive Oxygen Species NF-κB Autophagy
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .

HY-N12233

Condurango glycoside A	Apocynaceae Structural Classification Marsdenia cundurango Rchb.f. Polysaccharides Source classification Plants Saccharides	Apoptosis MDM-2/p53 Reactive Oxygen Species
Condurango glycoside A is an activator of p53. Condurango glycoside A initiates *ROS* generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells .

HY-N12653

Exserohilone (-)-Exserohilone	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Reactive Oxygen Species
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced *ROS* generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

HY-116506

Bigelovin	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Acacia auriculiformis A.Cunn. ex Benth Plants Compositae Disease Research Fields Cancer	RAR/RXR Reactive Oxygen Species Apoptosis Autophagy
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-N6020A

(+)-Butin	Flavonoids Dalbergia odorifera T. Chen Classification of Application Fields Leguminosae Flavonones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Others
(+)-Butin is the R enantiomer of Butin. Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera, with strong antioxidant, antiplatelet and anti-inflammatory activities .

HY-N2693

6,8-Diprenylorobol	Structural Classification Flavonoids Source classification Maclura tricuspidata Carriere Plants Moraceae Isoflavones	Apoptosis Reactive Oxygen Species Caspase Akt ERK JNK p38 MAPK Bcl-2 Family
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS .

HY-N6884

Bixin 1 Publications Verification	Bixaceae Bixa orellana Linn. Classification of Application Fields Ketones, Aldehydes, Acids Source classification Pigments Plants Inflammation/Immunology Disease Research Fields Cancer Food Research	Reactive Oxygen Species
Bixin (BX), isolated from the seeds of Bixa orellana, is a carotenoid, possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation .

HY-N0716B

Berberine sulfate 30+ Cited Publications Natural Yellow 18 sulfate	Alkaloids Structural Classification Classification of Application Fields Source classification Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

HY-N1306

Sideroxylin	Infection Eucalyptus saligna Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Myrtaceae Plants Disease Research Fields	Bacterial Reactive Oxygen Species Apoptosis
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against *Staphylococcus aureus. Sideroxylin inhibits ovarian cancer cell proliferation and induces apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation* of reactive oxygen species (ROS) .

HY-N10431

Stigmane B	Zea mays L. Terpenoids Gramineae Source classification Diterpenoids Plants	Keap1-Nrf2
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-N0232

Psoralidin 4 Publications Verification	Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Cancer	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial
Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces *ROS* generation .

HY-N3239

Mulberrofuran G	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	NADPH Oxidase HBV
Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress . Mulberrofuran G shows moderate inhibiting activity of hepatitis B virus (HBV) DNA replication with IC₅₀ of 3.99 μM .

HY-N0457

Chicoric acid 1 Publications Verification Cichoric acid; Dicaffeoyltartaric acid	Structural Classification Classification of Application Fields Anti-aging Source classification Other Phenylpropanoids Metabolic Disease Plants other families Phenols Polyphenols Phenylpropanoids Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species Apoptosis
Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects .

HY-N0716

Berberine Natural Yellow 18	Structural Classification Classification of Application Fields Anti-aging Source classification Ranunculaceae Plants Endogenous metabolite Biological Pesticide Research Agricultural Research Alkaloids Coptis chinensis Franch. Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Cancer	Topoisomerase Autophagy Bacterial Reactive Oxygen Species Endogenous Metabolite Antibiotic Parasite
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-N3071

Picrasidine I	Simaroubaceae Source classification Plants Quassia amaraL. Indole Alkaloids	Apoptosis Reactive Oxygen Species
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and *ROS* generation, and suppresses the expression of c-Fos and NFATc1 .

HY-N8413

Chlojaponilactone B	Structural Classification Terpenoids Sesquiterpenes Source classification Chloranthaceae Chloranthus japonicus Sieb. Plants	Toll-like Receptor (TLR) Reactive Oxygen Species NF-κB
Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α .

HY-119678

Fortunellin	Structural Classification Flavonoids Flavones Source classification Rutaceae Citrus japonica Thunb. Plants	AMPK Keap1-Nrf2
Fortunellin, is a flavonoid, that can be isolated from the fruits of Fortunella margarita (kumquat). Fortunellin exhibits little toxicity to mice and suppresses inflammation and ROS generation in H9C2 cells induced by LPS. Fortunellin protects against fructose-induced inflammation and oxidative stress by enhancing AMPK/Nrf2 pathway. Fortunellin can be used for diabetic cardiomyopathy research .

HY-N11648

Ganoderic acid T1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis Caspase
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .

HY-13065

Isobavachalcone 5+ Cited Publications Corylifolinin; Isobacachalcone	Structural Classification Classification of Application Fields Source classification Plants Chalcones Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Akt Reactive Oxygen Species Apoptosis Autophagy
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC₅₀ value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .

HY-50936

Trabectedin 3 Publications Verification Ecteinascidin 743; ET-743	Alkaloids Structural Classification Classification of Application Fields Animals Source classification Marine natural products Other marine organisms Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species Apoptosis
Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of *ROS* in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research .

HY-B0166

L-Ascorbic acid 35+ Cited Publications L-Ascorbate; Vitamin C	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Source classification Metabolic Disease Endocrine diseases Plants Endogenous metabolite Microorganisms Disease markers Moringaceae Nervous System Disorder Disease Research Fields	Reactive Oxygen Species Calcium Channel Apoptosis Endogenous Metabolite
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-N2515

Ginsenoside Rk1 3 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

Cat. No.	Product Name	Chemical Structure

HY-18258S

Berberine-d6 chloride
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].

HY-50936S

Trabectedin-d3

Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

HY-B0166S1

L-Ascorbic acid-13C

L-Ascorbic acid- ¹³C is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

HY-B0166S8

L-Ascorbic acid-13C6-1

L-Ascorbic acid- ¹³C₆-1 (L-Ascorbate-1; Vitamin C- ¹³C₆-1) is a ¹³C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-B0166S

L-Ascorbic acid-13C6

L-Ascorbic acid- ¹³C₆ is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

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